Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A. Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial. View abstract. Kondo K1, Shiba M, Nakamura R, Morota T, Shoyama Y. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. 2020;2020:3727682. View abstract. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Baba, M. and Shigeta, S. Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro. Yoon JY, Cha JM, Hong SS, et al. Schleimer, R. P. Potential regulation of inflammation in the lung by local metabolism of hydrocortisone. Int Endod.J 2011;44(1):51-58. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. View abstract. Prudden JF. Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. View abstract. Other conditions. Fitoterapia 2006;77(7-8):613-614. J Intern Med 1999;245:307-10. Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis -- double blind trial. Tsuda T, Sugaya A, Ohguchi H, et al. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Part 182 -- Substances Generally Recognized As Safe. Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. Am J Chin Med 2003;31:445-53. . The treatment of human cancer with agents prepared from bovine cartilage. View abstract. Prieto JM, Recio MC, Giner RM, et al. Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial. Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. Licorice might decrease how quickly the body breaks down methotrexate. 17. But the potential side effects are real enough. Volatiles with antimicrobial activity from the roots of Greek Paeonia taxa. Removes excess melanin: Licorice extract brightens the skin in another way, too. Kase Y, Saitoh K, Ishige A, et al. View abstract. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Front Psychiatry 2020;11:605949. Low doses of liquorice can induce hypertension encephalopathy. "Water pills" can also decrease potassium levels. Most clinical trials have found that when Peony is combined with Licorice Rt. View abstract. Engqvist, A., von Feilitzen, F., Pyk, E., and Reichard, H. Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. Caradonna, P., Gentiloni, N., Servidei, S., Perrone, G. A., Greco, A. V., and Russo, M. A. A man in Massachusetts died after eating too much black licorice, which contains a compound known to be toxic in large doses, according to a new report. But I didn't take it long enough to see any change. The effect of dong quai on menopausal symptoms is unknown. This versatile anti-inflammatory plant can benefit digestive issues, hormone health, and skin health as well as helping ease problems with menstruation and menopause. Drug Metab Dispos 2002;30:709-15.. View abstract. It has an effect similar to aldosterone. Lancet 2-10-1979;1(8111):319. The anti-estrogenic action of beta-glycyrrhetinic acid. It's not suggested to take St. John's wort if you take blood thinners. Deglycyrrhizinated liquorice in duodenal ulcer. View abstract. View abstract. Eur J Pharmacol 1981;72:219-25.. View abstract. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. View abstract. Lee, I. T., Lee, W. J., Tsai, C. M., Su, I. J., Yen, H. T., and Sheu, W. H. Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome. [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis]. *. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. A. and Cunliffe, W. J. Self-medication with liquorice in a patient with Addison's disease. Clin Rheumatol. Bell ZW, Canale RE, Bloomer RJ. Exp Neurol 1997;146:518-25. Kwon S, Jin C, Cho SY, et al. Cai Y, Yuan Q, Xu K, et al. View abstract. Phytother Res. Lower potassium levels can cause those abnormal heart arrhythmias. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. Liang Xiao, Wang YZ, Jing Liu, et al. Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection: a randomized, double-blind, placebo-controlled study. A., Braun, T. M., and Jacobson, J. J. View abstract. View abstract. View abstract. Z. Licorice that has had this substance removed (called DGL for deglycyrrhizinated licorice) may not have the same degree of side effects. Bardhan, K. D., Cumberland, D. C., Dixon, R. A., and Holdsworth, C. D. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. [Clinical characteristics of five elderly patients with severe hypokalemia induced by glycyrrhizin derivatives]. Li C, Wang ZB. Yamashiki, M., Nishimura, A., Suzuki, H., Sakaguchi, S., and Kosaka, Y. Celik, M. M., Karakus, A., Zeren, C., Demir, M., Bayarogullari, H., Duru, M., and Al, M. Licorice induced hypokalemia, edema, and thrombocytopenia. Lancet 2000;355(9198):134-138. Phytother Res 2008;22(6):709-724. View abstract. 2013 Sep;117(3):614-21. View abstract. Murakami, T. and Uchikawa, T. Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. Zong, P. P., Yan, T. Y., and Gong, M. M. [Clinical and experimental studies of effects of huayu decoction on scavenging free radicals]. View abstract. N Engl J Med 1990;322:850. But, she survived . 2016 Nov;48(11):1873-1880. doi: 10.1007/s11255-016-1345-5. Zhongguo Zhong.Xi.Yi Jie.He.Za Zhi 2008;28(12):1121-1123. 2003;23(8):593-595. View abstract. 1994;14:207-9, 195. . Yamamoto, T., Hatanaka, M., Matsuda, J., Kadoya, H., Takahashi, A., Namba, T., Takeji, M., and Yamauchi, A. All rights reserved. Chemical studies of Chinese licorice-roots. View abstract. Lancet 1992;340:13-17. Gut 1973;14(9):711-715. Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. WebMD does not provide medical advice, diagnosis or treatment. Menopause 2002;9:145-50. View abstract. Murck H, Lehr L, Hahn J, Braunisch MC, Jezova D, Zavorotnyy M. Adjunct Therapy With Glycyrrhiza Glabra Rapidly Improves Outcome in Depression-A Pilot Study to Support 11-Beta-Hydroxysteroid Dehydrogenase Type 2 Inhibition as a New Target. The herb has also been studied for use in canine atopic dermatitis along with white peony (Paeonia lactiflora) and licorice (Glycyrrhiza glabra). An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Therapeutic Research Faculty 2020. Little is known about whether it's safe to use licorice root while breastfeeding. View abstract. Additional reporting by Meghan De Maria. View abstract. Hum.Exp Toxicol. [Comparison of pre- and post-treatmental hepatohistology with heavy dosage of Paeonia rubra on chronic active hepatitis caused liver fibrosis]. Anesth Analg. Eisenburg, J. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. View abstract. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Journal of Clinical Therapeutics Medicine. View abstract. Farese RV Jr, Biglieri EG, Shackleton CH, et al. . View abstract. View abstract. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. Antiviral Res 1987;7(2):99-107. Int Immunopharmacol. View abstract. View abstract. Although some people believe that peony tea is the tea with the lowest caffeine levels, actually peony tea has a high caffeine level, as much as 5%. Evid Based Complement Alternat Med 2016;2016:8292486. Br J Clin Pract 1972;26(12):563-566. Clinical and immunological consequences of total glucosides of paeony treatment in Sjgren's syndrome: A randomized controlled pilot trial. Select a condition to view a list of vitamins. View abstract. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. J Ethnopharmacol 2002;81:101-4.. View abstract. Yu C, Fan X, Li Z, Liu X, Wang G. Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial. 2011;25(2):312-313. View abstract. View abstract. Wu G, Wu N, Li T, et al. Lapi F, Gallo E, Bernasconi S, et al. Kumada T, et al. Thom E and Wollan T. A controlled clinical study of kanjang mixture in the treatment of uncomplicated upper respiratory tract infections. A., Torres Murillo J., and Calderon de la Barca Gazquez J. M. [Acute rhabdomyolysis and tetraparesis secondary to hypokalemia due to ingested licorice]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28(4):314-317. Preterm birth and licorice consumption during pregnancy. View abstract. 2020;45(2):257-264. Amaryan G, Astvatsatryan V, Gabrielyan E, et al. Licorice. Taking licorice along with "water pills" might make potassium levels drop too low. View abstract. Some of these health benefits have also . J Peripher.Nerv.Syst. Kumada T, et al. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity. Antiviral Res 1987;7(3):127-137. The biological compound pesticide is manufactured from the raw materials of Ailanthus altissima Swingle, Cyrtomium fortunei, geranium wilfordii, fructus forsythiae, Scutellaria baicalensis, gallnut, areca-nut, coconut shell, radix sophorae . World J Gastroenterol 2-7-2006;12(5):760-764. For people who already have high blood pressure or heart or kidney disease, as little as 5 g/day can cause these side effects. Lipids Health Dis 2011;10:29. Hajiaghamohammadi, A. View abstract. View abstract. Epilepsy Res 2021;176:106735. Pharm Biol. Licorice consumption and serum testosterone in healthy man. Sakamoto, S., Yoshino, H., Shirahata, Y., Shimodairo, K., and Okamoto, R. Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. The efficacy and safety of the combination of total glucosides of peony and leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Ha Y, Wang T, Li J, et al. Oral Dis 2012;18(1):32-39. Nephron 2002;90:240. [13] A study in Japan compared the use of a . View abstract. View abstract. View abstract. The dogs treated with the herbal mixture saw a 37.5 percent improvement . View abstract. The invention belongs to the field of biopesticides, and mainly discloses a nuisanceless biological compound pesticide and a preparation method thereof. Licorice might increase how quickly the body breaks down paclitaxel. Contact Dermatitis 2021;85(4):454-455. A double-blind, randomized, placebo-controlled, multicenter trial. View abstract. Cinatl J, Morgenstern B, Bauer G, et al. Some birth control pills contain estrogen. Zhong Yao Cai 2000;23:557-60. . Biol Pharm Bull. Shen, A. Y., Wang, T. S., Huang, M. H., Liao, C. H., Chen, S. J., and Lin, C. C. Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Benge E, Shah P, Yamaguchi L, Josef V. Trick or Treat? Effect of shakuyaku-kanzoh-toh, a prescription composed of shakuyaku (Paeoniae Radix) and kanzoh (Glycyrrhizae Radix) on guinea pig ileum. View abstract. Altern Med Rev 1999;4(3):178-188. Sigurjonsdottir HA, Franzson L, Manhem K, et al. View abstract. Arch Pharm Res 2002;25(3):293-299. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. Clin Exp Obstet Gynecol 2013;40(1):141-143. View abstract. Madisch A, Holtmann G, Mayr G, et al. Acharya SK, Dasarathy S, Tandon A, et al. 1987;(10):46-48. Br J Dermatol 1992;126:179-84. Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. 2019;38(3):657-64. Am J Chin Med 1996;24:165-8. Read more. The Potential Benefits and Side Effects of the White Peony Root. Iran J Pharm Res 2012;11(2):541-8. Takahara T, Watanabe A, Shiraki K. Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. 2 in the perioperative stage of laparoscopic cholecystectomy]. View abstract. Foster CA, Church KS, Poddar M, Van Uum SH, Spaic T. Licorice-induced hypertension: a case of pseudohyperaldosteronism due to jelly bean ingestion. Traditionally, white peony root is used for treating a wide range of health ailments, like inflammation, pain, and many more. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. Erratum in: Clin Rheumatol. View abstract. If you take birth control pills along with peony, use an additional form of birth control such as a condom. View abstract. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. Zhonghua Yi Xue Za Zhi 1983;63:477-81. B., and Zhang, Z. J. Association of emblica, licorice and belides as an alternative to hydroquinone in the clinical treatment of melasma. View abstract. Hypokalemic paralysis due to licorice consumption is extremely rare, with only 40 cases in the English literature describing paralysis secondary to exposure to licorice in candies, medications, chewing tobacco, and herbal preparations. View abstract. 2013 Jun;19(4):227-8. J Pharmacobiodyn 1983;6:153-60. . Phytomedicine 2003;10:271-85. Hyodo T, Taira T, Kumakura M, et al. Chin, Y. W., Jung, H. A., Liu, Y., Su, B. N., Castoro, J. Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract. View abstract. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. View abstract. J Neuroophthalmol. and its bioactive compounds. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Early evidence suggests that taking 45 grams of a specific product containing peony and licorice (Peony-Glycyrrhiza Decoction, PGD) daily for 4 weeks reduces levels of a hormone called prolactin in women with high levels of prolactin, without affecting other hormone levels or mental symptoms. Kroes, B. H., Beukelman, C. J., van den Berg, A. J., Wolbink, G. J., van Dijk, H., and Labadie, R. P. Inhibition of human complement by beta-glycyrrhetinic acid. View abstract. J Dermatolog Treat 2003;14(3):153-157. Man SC, Li XB, Wang HH, et al. View abstract. 30. View abstract. Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report. A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing. View abstract. Yang F, Qi X, Du Y, et al. Licorice roots can be consumed directly to get relief from cough and sore throat. Man SC, Li XB, Wang HH, et al. Zhong.Xi.Yi.Jie.He.Za Zhi. Tamir S, Eizenberg M, Somjen D, et al. Anon. Harada M, Suzuki M, Ozaki Y. Eur.Arch.Paediatr.Dent 2010;11(6):274-278. Liu X, Li X, Li X, et al. View abstract. View abstract. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. Dying for a cup of tea. Zhong Xi Yi Jie He Za Zhi 1990;10:101-2, 70. . WebMD does not provide medical advice, diagnosis or treatment. A specific type of peony product, total glucosides of peony (TGP), has most often been used by adults in doses of 600 mg by mouth three times daily for up to 24 weeks. Luchon, L., Meyrier, A., and Paillard, F. [Hypokalemia without arterial hypertension by licorice poisoning]. Holtmann G, Madisch A, Juergen H, et al. Ann Noninvasive Electrocardiol. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Kang, D. G., Moon, M. K., Choi, D. H., Lee, J. K., Kwon, T. O., and Lee, H. S. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. View abstract. View abstract. View abstract. Rev Med Brux 2008;29(5):490-493. Nussbaumer, U., Landolt, M., Rothlisberger, G., Akovbiantz, A., Keller, H., Weber, E., Blum, A. L., and Peter, P. [Postoperative stress hemorrhage: ineffective prevention with pepsin inhibitor and deglycyrrhizinized licorice extract. Das SK, Das V, Gulati AK, and et al. 2005 - 2023 WebMD LLC. Zhongguo Zhong.Xi.Yi Jie.He.Za Zhi 2008;28(4):358-360. Mitscher, L. A., Park, Y. H., Clark, D., and Beal, J. L. Antimicrobial agents from higher plants. About Dr.Cope. Anesth Analg 2009;109(1):77-81. View abstract. View abstract. Am J Respir.Cell Mol.Biol. That's because licorice real black licorice, not the phony licorice-flavored stuff flavored with anise oil . Pakravan F, Salehabad NH, Karimi F, Isfahani MN. An Med Interna 1995;12(1):33-35. West J Med 1997;167(3):184-185. Peony root might decrease the amount of phenytoin in the body. Mumoli, N. and Cei, M. Licorice-induced hypokalemia. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Side effects of peony tea! Medicinal uses of licorice through the millennia: the good and plenty of it. One major reported side effect of licorice root is reduced levels of testosterone in men ( 10 ). Large amounts of licorice can decrease potassium levels in the body. Exp Clin Endocrinol Diabetes 2003;111:341-3. Some research studies have found Angelica Sinensis to be beneficial for its effects on some symptoms of menopause. Riv Patol Nerv Ment 1983;104(4):179-183. The dose of your warfarin might need to be changed. Yang DG. Apparantly it's the one most important thing that shouldn't mix with Prednisolone and it makes withdrawal symptoms much worse. Taking too much licorice can cause high blood pressure. Hyodo T, Taira T, Kumakura M, et al. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. View abstract. Burgess, J. View abstract. Yuan, H. N., Wang, C. Y., Sze, C. W., Tong, Y., Tan, Q. R., Feng, X. J., Liu, R. M., Zhang, J. 2014 Jun;20(6):516-20. mentioned adverse effects and recurrence rates. Rackova, L., Jancinova, V., Petrikova, M., Drabikova, K., Nosal, R., Stefek, M., Kostalova, D., Pronayova, N., and Kovacova, M. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. Kim, H. J., Chang, E. J., Bae, S. J., Shim, S. M., Park, H. D., Rhee, C. H., Park, J. H., and Choi, S. W. Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora.